tailieunhanh - Báo cáo y học: "Therapeutic impact of the ethyl acetate extract of Tripterygium wilfordii Hook F on nephritis in NZB/W F1 mice"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài:Therapeutic impact of the ethyl acetate extract of Tripterygium wilfordii Hook F on nephritis in NZB/W F1 mice. | Available online http content 8 1 R24 Research article Therapeutic impact of the ethyl acetate extract of Tripterygium wilfordii Hook F on nephritis in NZB W F1 mice Xuelian Tao1 Fred Fan1 Victoria Hoffmann2 Nancy S Longo1 and Peter E Lipsky1 Autoimmunity Branch National Institute of Arthritis and Musculoskeletal and Skin Diseases National Institutes of Health Rockville Pike Bethesda MD 20892 USA 2Office of Research Services Division of Veterinary Resources National Institutes of Health Rockville Pike Bethesda MD 20892 USA Corresponding author Peter E Lipsky lipskyp@ Received 1 Nov 2005 Revisions requested 24 Nov 2005 Revisions received 6 Dec 2005 Accepted 6 Dec 2005 Published 3 Jan 2006 Arthritis Research Therapy 2006 8 R24 doi ar1879 This article is online at http content 8 1 R24 2006 Tao et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract This study was designed to examine the potential use of the ethyl acetate EA extract of Tripterygium wilfordii Hook F TwHF a Chinese herbal medicine in the treatment of systemic lupus erythematosus. A total of 48 28-week-old female NZB W F1 mice were randomly divided into three groups and orally administered vehicle or the EA extract of TwHF at mg kg EAlow or mg kg EAhigh for 14 weeks. Proteinuria and serum anti-double-stranded ds DNA antibody titers were assayed before and after treatment. At the end of treatment all animals were sacrificed and pathological changes in the kidneys were examined by observers blinded to the treatment regimens. Immunohistological studies were carried out on kidneys and spleens. At 28 weeks of age proteinuria 30 mg dl and anti-dsDNA antibodies were found in