tailieunhanh - Báo cáo y học: "κ The TRAF6-NFκB signaling pathway in autoimmunity: not just inflammation"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: κ The TRAF6-NFκB signaling pathway in autoimmunity: not just inflammation. | Arthritis Research Therapy August 2005 Vol 7 No 4 Thomas Viewpoint The TRAF6-NFkB signaling pathway in autoimmunity not just inflammation Ranjeny Thomas Centre for Immunology and Cancer Research Princess Alexandra Hospital University of Queensland Brisbane Australia Corresponding author Ranjeny Thomas rthomas@ Published 23 June 2005 This article is online at http content 7 4 170 2005 BioMed Central Ltd Arthritis Research Therapy 2005 7 170-173 DOI ar1784 Recently Akiyama et al. 1 described defects in thymic negative selection and in CD4 CD25 regulatory T cell production in mice deficient for tumor necrosis factor TNF receptor associated factor TRAF 6. Signaling through cell surface receptors to activate nuclear factor NF kB and mitogen-activated protein MAP kinases through adaptor molecules including TRAF6 is of critical importance to survival and activation of all cells in the body from those regulating the immune response to epithelial cells with which immunocytes interact Fig. 1 . Because the same cell signaling pathways regulate survival and activation in the periphery and in the thymus however mutations or polymorphisms in the pathway can have outcomes for the immune system that might have been difficult to predict. This is because survival and activation of key antigen presenting cells APCs medullary thymic epithelial cells mTECs and dendritic cells DCs involved in thymic negative selection and peripheral immunity are regulated by a similar network of genes which map a pathway from TRAF6 to the NFkB family member RelB. Thymic selection and autoimmunity The vast majority of T cells arise in the thymus. In the fetal and neonatal period central tolerance is actively maintained in the thymus 2 . During this process a repertoire of T cells restricted to self-MHC displayed by the thymic cortical epithelial cells cTECs is selected in each individual. In addition those T cells reactive to self-antigen presented by .