tailieunhanh - Báo cáo y học: "ADAMTS proteinases: a multi-domain, multi-functional family with roles in extracellular matrix turnover and arthritis"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: ADAMTS proteinases: a multi-domain, multi-functional family with roles in extracellular matrix turnover and arthritis. | Arthritis Research Therapy August 2005 Vol 7 No 4 Jones and Riley Review ADAMTS proteinases a multi-domain multi-functional family with roles in extracellular matrix turnover and arthritis Gavin C Jones and Graham P Riley Rheumatology Research Unit Addenbrooke s Hospital Cambridge UK Corresponding author Gavin C Jones gjj23@ Published 21 June 2005 This article is online at http content 7 4 160 2005 BioMed Central Ltd Arthritis Research Therapy 2005 7 160-169 DOI ar1783 Abstract Members of the ADAMTS a disintegrin and metalloproteinase with thrombospondin motifs family are known to influence development angiogenesis coagulation and progression of arthritis. As proteinases their substrates include the von Willebrand factor precursor and extracellular matrix components such as procollagen hyalectans hyaluronan-binding proteoglycans including aggrecan decorin fibromodulin and cartilage oligomeric matrix protein. ADAMTS levels and activities are regulated at multiple levels through the control of gene expression mRNA splicing protein processing and inhibition by TIMP tissue inhibitor of metalloproteinases . A recent screen of human cartilage has shown that multiple members of the ADAMTS family may be important in connective tissue homeostasis and pathology. Introduction ADAMTS a disintegrin and metalloproteinase with thrombospondin motifs proteinases are a group of secreted enzymes many of them have been found to be expressed in cartilage 1 . Functional investigations of these enzymes have largely been limited to a few specific members particularly ADAMTS-4 which has been implicated in the progression of arthritis 2 3 . The purpose of this review is to summarise the structure function and regulation of the entire ADAMTS group of proteinases and to emphasise areas of potential relevance with regard to the homeostasis and pathology of connective tissues. ADAMTS evolution and structure ADAMTS proteinases were first described in mice