tailieunhanh - Báo cáo y học: "Prevalence of opioid adverse events in chronic non-malignant pain: systematic review of randomised trials of oral opioid"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Prevalence of opioid adverse events in chronic non-malignant pain: systematic review of randomised trials of oral opioids. | Available online http content 7 5 R1046 Research article Prevalence of opioid adverse events in chronic non-malignant pain systematic review of randomised trials of oral opioids R Andrew Moore and Henry J McQuay Pain Research and Nuffield Department of Anaesthetics University of Oxford Oxford Radcliffe Hospital Oxford UK Corresponding author R Andrew Moore Received 18 Apr 2005 Revisions requested 18 May 2005 Revisions received 24 May 2005 Accepted 6 Jun 2005 Published 28 Jun 2005 Arthritis Research Therapy 2005 7 R1046-R1051 DOI ar1782 This article is online at http content 7 5 R1046 2005 Moore and McQuay licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Adverse events of opioids may restrict their use in non-cancer pain. Analysis of the incidence of common adverse events in trials conducted in non-cancer pain has usually been limited to opioids used to treat severe pain according to the WHO three-step ladder. To examine the incidence of common adverse events of opioids in non-cancer pain a systematic review and meta-analysis of information from randomised trials of all opioids in non-cancer pain was undertaken. Studies used were published randomised trials of oral opioid in non-cancer pain with placebo or active comparator. Thirty-four trials with 5 546 patients were included with 4 212 patients contributing some information on opioid adverse events. Most opioids used accounting for 90 of patients were for treating moderate rather than severe pain. Including trials without a placebo increased the amount of information available by times. Because of clinical heterogeneity in condition opioid opioid dose duration and use of

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