tailieunhanh - Báo cáo y học: " Imbalance of local bone metabolism in inflammatory arthritis and its reversal upon tumor necrosis factor blockade: direct analysis of bone turnover in murine arthritis"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Imbalance of local bone metabolism in inflammatory arthritis and its reversal upon tumor necrosis factor blockade: direct analysis of bone turnover in murine arthritis. | Available online http content 8 1 R22 Open Access Research article Imbalance of local bone metabolism in inflammatory arthritis and its reversal upon tumor necrosis factor blockade direct analysis of bone turnover in murine arthritis Jochen Zwerina Birgit Tuerk Kurt Redlich Josef S Smolen and Georg Schett Division of Rheumatology Department of Internal Medicine III Medical University of Vienna Waehringer Guertel 18-20 A-1090 Vienna Austria Corresponding author Georg Schett Received 1 7 Aug 2005 Revisions requested 26 Sep 2005 Revisions received 18 Oct 2005 Accepted 25 Nov 2005 Published 30 Dec 2005 Arthritis Research Therapy 2006 8 R22 doi ar1 872 This article is online at http content 8 1 R22 2005 Zwerina et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Chronic arthritis typically leads to loss of periarticular bone which results from an imbalance between bone formation and bone resorption. Recent research has focused on the role of osteoclastogenesis and bone resorption in arthritis. Bone resorption cannot be observed isolated however since it is closely linked to bone formation and altered bone formation may also affect inflammatory bone loss. To simultaneously assess bone resorption and bone formation in inflammatory arthritis we developed a histological technique that allows visualization of osteoblast function by in-situ hybridization for osteocalcin and osteoclast function by histochemistry for tartrate-resistant acid phosphatase. Paw sections from human tumor necrosis factor transgenic mice which develop an erosive arthritis were analyzed at three different skeletal sites subchondral bone erosions adjacent cortical .