tailieunhanh - Báo cáo y học: "The active metabolite of leflunomide, A77 1726, interferes with dendritic cell function"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: The active metabolite of leflunomide, A77 1726, interferes with dendritic cell function. | Available online http content 7 3 R694 Research article The active metabolite of leflunomide A77 1726 interferes with dendritic cell function Bernhard M Kirsch1 Maximilian Zeyda2 Karl Stuhlmeier3 Johannes Grisar4 Josef S Smolen4 5 Bruno Watschinger1 Thomas M Stulnig2 5 Walter H Horl1 Gerhard J Zlabinger6 and Marcus D Saemann1 Open Access Department of Internal Medicine III Clinical Divisions of Nephrology and Dialysis Medical University of Vienna Vienna Austria department of Internal Medicine III Clinical Divisions of Endocrinology and Metabolism Medical University of Vienna Vienna Austria 3Ludwig Boltzmann Institute of Rheumatology Vienna Austria department of Internal Medicine III Clinical Division of Rheumatology Medical University of Vienna Vienna Austria 5CeMM - Center of Molecular Medicine Austrian Academy of Sciences Vienna Austria institute of Immunology Medical University of Vienna Vienna Austria Corresponding author Marcus D Saemann Received 16 Dec 2004 Revisions requested 21 Jan 2005 Revisions received 23 Feb 2005 Accepted 1 Mar 2005 Published 1 Apr 2005 Arthritis Research Therapy 2005 7 R694-R703 DOI 86 ar1 727 This article is online at http content 7 3 R694 2005 Kirsch et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Leflunomide a potent disease-modifying antirheumatic drug used in the treatment of rheumatoid arthritis RA exhibits antiinflammatory antiproliferative and immunosuppressive effects. Although most of the beneficial effects of leflunomide have been attributed to its antimetabolite activity mainly in T cells other targets accounting for its potency might still exist. Because of mounting evidence for a .

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