tailieunhanh - Báo cáo y học: "Intra-articular injections of high-molecular-weight hyaluronic acid have biphasic effects on joint inflammation and destruction in rat antigen-induced arthritis"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Intra-articular injections of high-molecular-weight hyaluronic acid have biphasic effects on joint inflammation and destruction in rat antigen-induced arthritis. | Available online http content 7 3 R677 Research article Intra-articular injections of high-molecular-weight hyaluronic acid have biphasic effects on joint inflammation and destruction in rat antigen-induced arthritis Andreas Roth1 Jurgen Mollenhauer1 2 Andreas Wagner1 Reneè Fuhrmann1 Albrecht Straub1 Rudolf A Venbrocks1 Peter Petrow3 Rolf Brauer3 Harald Schubert4 Jorg Ozegowski5 Gundela Peschel6 Peter J Muller6 and Raimund W Kinne7 Open Access Department of Orthopaedics Rudolf-Elle Hospital Friedrich Schiller University Jena Eisenberg Germany 2Department of Biochemistry Rush Medical College Head Chicago Illinois USA institute of Pathology Friedrich Schiller University Jena Germany 4Institute of Animal Studies Friedrich Schiller University Jena Germany institute of Biochemistry 2 Friedrich Schiller University Jena Germany 6Hans Knoell Institute for Natural Products Research Jena Germany Experimental Rheumatology Unit Friedrich Schiller University Jena Germany Corresponding author Andreas Roth ajroth@ Received 6 Dec 2004 Revisions requested 23 Feb 2005 Revisions received 23 Feb 2005 Accepted 1 Mar 2005 Published 31 Mar 2005 Arthritis Research Therapy 2005 7 R677-R686 DOI 86 ar1 725 This article is online at http content 7 3 R677 2005 Roth et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is cited. Abstract To assess the potential use of hyaluronic acid HA as adjuvant therapy in rheumatoid arthritis the anti-inflammatory and chondroprotective effects of HA were analysed in experimental rat antigen-induced arthritis AIA . Lewis rats with AIA were subjected to short-term days 1 and 8 n 10 or long-term days 1 8 15 and 22 n 10 intra-articular treatment with microbially manufactured .