tailieunhanh - Báo cáo y học: "Intra-articular injection of recombinant TRAIL induces synovial apoptosis and reduces inflammation in a rabbit knee model of arthri"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Intra-articular injection of recombinant TRAIL induces synovial apoptosis and reduces inflammation in a rabbit knee model of arthritis. | Available online http content 8 1 R16 Open Access Research article Intra-articular injection of recombinant TRAIL induces synovial apoptosis and reduces inflammation in a rabbit knee model of arthritis Qingping Yao1 Dai-Wu Seol2 Zhibao Mi1 and Paul D Robbins1 1 Department of Molecular Genetics and Biochemistry 200 Lothrop Street University of Pittsburgh School of Medicine Pittsburgh PA 15261 USA 2Department of Surgery 200 Lothrop Street University of Pittsburgh School of Medicine Pittsburgh PA 15261 USA Corresponding author Paul D Robbins probb@ Received 28 May 2005 Revisions requested 23 Jun 2005 Revisions received 10 Oct 2005 Accepted 15 Nov 2005 Published 16 Dec 2005 Arthritis Research Therapy 2006 8 R16 doi ar1 867 This article is online at http content 8 1 R1 6 2005 Yao et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract We demonstrated previously that local intra-articular injection of an adenoviral vector expressing human tumor necrosis factor-related apoptosis-inducing ligand TRAIL in a rabbit knee model of inflammatory arthritis stimulated synovial apoptosis and reduced inflammation. To examine whether intra-articular injection of recombinant chimeric human TRAIL protein rTRAIL also induces apoptosis of proliferating rabbit synovium and reduces inflammation we used an experimental rabbit arthritis model of rheumatoid arthritis induced by intra-articular introduction of allogeneic fibroblasts genetically engineered to secrete human IL-1p. Analysis of synovium isolated from the rabbits treated with intra-articular injection of rTRAIL relative to saline control showed areas of extensive acellular debris and large fibrous regions devoid of intact

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