tailieunhanh - Báo cáo y học: "Modeling human arthritic diseases in nonhuman primates"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Modeling human arthritic diseases in nonhuman primates. | Available online http contents 7 4 145 Review Modeling human arthritic diseases in nonhuman primates Michel PM Vierboom Margreet Jonker Ronald E Bontrop and Bert t Hart Departments of Immunobiology and Comparative Genetics Biomedical Primate Research Centre Rijswijk The Netherlands Corresponding author Michel PM Vierboom vierboom@ Published 9 June 2005 This article is online at http content 7 4 145 2005 BioMed Central Ltd Arthritis Research Therapy 2005 7 145-154 DOI ar1773 Abstract Models of rheumatoid arthritis RA in laboratory animals are important tools for research into pathogenic mechanisms and the development of effective safe therapies. Rodent models rats and mice have provided important information about the pathogenic mechanisms. However the evolutionary distance between rodents and humans hampers the translation of scientific principles into effective therapies. The impact of the genetic distance between the species is especially seen with treatments based on biological molecules which are usually species-specific. The outbred nature and the closer anatomical genetic microbiological physiological and immunological similarity of nonhuman primates to humans may help to bridge the wide gap between inbred rodent strain models and the heterogeneous RA patient population. Here we review clinical immunological and pathological aspects of the rhesus monkey model of collagen-induced arthritis which has emerged as a reproducible model of human RA in nonhuman primates. Introduction Rheumatoid arthritis RA is a chronic inflammatory disease of unknown etiology 1 2 . Once established immune reactions against joint components contribute significantly to the pathological hallmarks of the disease being synovial hyperplasia pannus formation and a variable degree of destruction and remodeling of joint cartilage and bone. RA affects approximately 1 of people in Western countries with a 2 1 prevalence in females .