tailieunhanh - Báo cáo y học: "Dermatological conditions during TNF-α-blocking therapy in patients with rheumatoid arthritis: a prospective study"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Dermatological conditions during TNF-α-blocking therapy in patients with rheumatoid arthritis: a prospective study. | Available online http content 7 3 R666 Research article Dermatological conditions during TNF-a-blocking therapy in patients with rheumatoid arthritis a prospective study Marcel Flendrie1 Wynand HPM Vissers2 Marjonne CW Creemers1 Elke MGJ de Jong2 Peter CM van de Kerkhof2 and Piet LCM van Riel1 Open Access Department of Rheumatology Radboud University Nijmegen Medical Centre Nijmegen the Netherlands 2Department of Dermatology Radboud University Nijmegen Medical Centre Nijmegen the Netherlands Corresponding author Marcel Flendrie Received 3 Jan 2005 Revisions requested 20 Jan 2005 Revisions received 25 Feb 2005 Accepted 1 Mar 2005 Published 4 Apr 2005 Arthritis Research Therapy 2005 7 R666-R676 DOI 86 ar1 724 This article is online at http content 7 3 R666 2005 Flendrie et al. licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Various dermatological conditions have been reported during tumor necrosis factor TNF -a-blocking therapy but until now no prospective studies have been focused on this aspect. The present study was set up to investigate the number and nature of clinically important dermatological conditions during TNF-a-blocking therapy in patients with rheumatoid arthritis RA . RA patients starting on TNF-a-blocking therapy were prospectively followed up. The numbers and natures of dermatological events giving rise to a dermatological consultation were recorded. The patients with a dermatological event were compared with a group of prospectively followed up RA control patients naive to TNF-a-blocking therapy and matched for follow-up period. 289 RA patients started TNF-a-blocking therapy. 128 dermatological events were recorded in 72 .