tailieunhanh - Báo cáo y học: "Partial protection against collagen antibody-induced arthritis in PARP-1 deficient mice"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Partial protection against collagen antibody-induced arthritis in PARP-1 deficient mice. | Available online http content 8 1 R14 Research article Partial protection against collagen antibody-induced arthritis in PARP-1 deficient mice Samuel García1 Ana Bodano1 Antonio Gonzalez1 Jeronimo Forteza2 Juan J Gómez-Reino3 and Carmen Conde1 Research Laboratory Hospital Clínico Universitario Choupana s n 15706-Santiago de Compostela Spain 2Department of Pathology Hospital Clínico Universitario Choupana s n 15706-Santiago de Compostela Spain 3Rheumatology Unit Hospital Clínico Universitario and Department of Medicine Universidad de Santiago San Francisco s n 15700-Santiago de Compostela Spain Corresponding author Carmen Conde Received 18 Feb 2005 Revisions requested 16 Mar 2005 Revisions received 8 Nov 2005 Accepted 9 Nov 2005 Published 6 Dec 2005 Arthritis Research Therapy 2006 8 R14 doi ar1 865 This article is online at http content 8 1 R1 4 2005 García et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Poly ADP-ribose polymerase-1 PARP-1 is a nuclear DNA-binding protein that participates in the regulation of DNA repair and maintenance of genomic integrity. In addition PARP-1 has a role in several models of inflammation disease where its absence or inactivation confers protection. The aim of this study was to analyze the impact of selective PARP-1 suppression in collagen antibody-induced arthritis. We show that PARP-1 deficiency partially reduces the severity of arthritis although the incidence of disease was similar in control and deficient mice. Decreased clinical scores were accompanied by partial reduction of histopathological findings. Interestingly quantitative real-time PCR and ELISA analysis revealed that .

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