tailieunhanh - Báo cáo y học: "Serum protein profile in systemic-onset juvenile idiopathic arthritis differentiates response versus nonresponse to therapy"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Serum protein profile in systemic-onset juvenile idiopathic arthritis differentiates response versus nonresponse to therapy. | Available online http content 7 4 R746 Research article Serum protein profile in systemic-onset juvenile idiopathic arthritis differentiates response versus nonresponse to therapy Takako Miyamae1 David E Malehorn2 Bonnie Lemster1 Masaaki Mori3 Tomoyuki Imagawa3 Shumpei Yokota3 William L Bigbee2 Manda Welsh2 Klaus Klarskov4 Norihiro Nishomoto5 Abbe N Vallejo1 and Raphael Hirsch1 Division of Rheumatology Children s Hospital of Pittsburgh Department of Pediatrics University of Pittsburgh School of Medicine Pittsburgh PA 15213 2University of Pittsburgh Cancer Institute University of Pittsburgh School of Medicine Pittsburgh PA 15213 3Department of Pediatrics Yokohama City University School of Medicine Yokohama Japan 4Départment de Phamacologie Faculte de Medicine Université de Sherbrooke Quebec Canada 5Osaka University Osaka Japan Corresponding author Raphael Hirsch Received 20 Jan 2005 Revisions requested 22 Feb 2005 Revisions received 26 Feb 2005 Accepted 28 Feb 2005 Published 4 Apr 2005 Arthritis Research Therapy 2005 7 R746-R755 DOI 86 ar1 723 This article is online at http content 7 4 R746 2005 Miyamae et al. licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Systemic-onset juvenile idiopathic arthritis SJIA is a disease of unknown etiology with an unpredictable response to treatment. We examined two groups of patients to determine whether there are serum protein profiles reflective of active disease and predictive of response to therapy. The first group n 8 responded to conventional therapy. The second group n 15 responded to an experimental antibody to the IL-6 receptor MRA . Paired sera from each patient were analyzed before and