tailieunhanh - Báo cáo y học: "CD134 as target for specific drug delivery to T cells in adjuvant arthritis"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: CD134 as target for specific drug delivery to T cells in adjuvant arthritis. | Available online http content 7 3 R604 Research article CD134 as target for specific drug delivery to auto-aggressive CD4 T cells in adjuvant arthritis Elmieke PJ Boot1 2 Gerben A Koning1 Gert Storm1 Josée PA Wagenaar-Hilbers2 Willem van Eden2 Linda A Everse1 2 and Marca HM Wauben2 Open Access Department of Pharmaceutics Utrecht Institute for Pharmaceutical Sciences Utrecht University Utrecht The Netherlands 2Division of Immunology Department of Infectious Diseases and Immunology Faculty of Veterinary Medicine Utrecht University Utrecht The Netherlands Corresponding author Marca HM Wauben Received 7 Dec 2004 Revisions requested 18 Jan 2005 Revisions received 3 Feb 2005 Accepted 24 Feb 2005 Published 21 Mar 2005 Arthritis Research Therapy 2005 7 R604-R615 DOI 86 ar1 722 This article is online at http content 7 3 R604 2005 Boot et al. licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract T cells have an important role during the development of autoimmune diseases. In adjuvant arthritis a model for rheumatoid arthritis we found that the percentage of CD4 T cells expressing the activation marker CD134 OX40 antigen was elevated before disease onset. Moreover these CD134 T cells showed a specific proliferative response to the disease-associated epitope of mycobacterial heat shock protein 60 indicating that this subset contains auto-aggressive T cells. We studied the usefulness of CD134 as a molecular target for immune intervention in arthritis by using liposomes coated with a CD134-directed monoclonal antibody as a drug targeting system. Injection of anti-CD134 liposomes subcutaneously in the hind paws of pre-arthritic rats resulted in targeting of the .