tailieunhanh - Báo cáo y học: "ncreased serum HO-1 in hemophagocytic syndrome and adult-onset Still's disease: use in the differential diagnosis of hyperferritinemia"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Increased serum HO-1 in hemophagocytic syndrome and adult-onset Still's disease: use in the differential diagnosis of hyperferritinemia. | Available online http content 7 3 R616 Research article Increased serum HO-1 in hemophagocytic syndrome and adult-onset Still s disease use in the differential diagnosis of hyperferritinemia Yohei Kirino1 Mitsuhiro Takeno1 Mika Iwasaki1 Atsuhisa Ueda1 Shigeru Ohno1 Akira Shirai1 Heiwa Kanamori1 Katsuaki Tanaka2 and Yoshiaki Ishigatsubo1 1Department of Internal Medicine and Clinical Immunology Yokohama City University Graduate School of Medicine Yokohama Japan 2Yokohama City University Medical Center Department of Gastroenterological Center Yokohama Japan Corresponding author Yoshiaki Ishigatsubo ishigats@ Received 8 Dec 2004 Revisions requested 26 Jan 2005 Revisions received 17 Feb 2005 Accepted 21 Feb 2005 Published 21 Mar 2005 Arthritis Research Therapy 2005 7 R616-R624 DOI 86 ar1 721 This article is online at http content 7 3 R616 2005 Kirino et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Heme oxygenase-1 HO-1 an inducible heme-degrading enzyme is expressed by macrophages and endothelial cells in response to various stresses. Because ferritin synthesis is stimulated by Fe2 which is a product of heme degradation we examined the relation between HO-1 and ferritin levels in the serum of patients with hemophagocytic syndrome HPS adultonset Still s disease ASD and other diseases that may cause hyperferritinemia. Seven patients with HPS 10 with ASD 73 with other rheumatic diseases 20 with liver diseases 10 recipients of repeated blood transfusion because of hematological disorders and 22 healthy volunteers were enrolled. Serum HO-1 and ferritin levels were determined by ELISA. Expression of HO-1 mRNA and protein by peripheral .