tailieunhanh - Báo cáo y học: "egulatory T cells in rheumatoid arthritis"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Regulatory T cells in rheumatoid arthritis. | Available online http contents 7 3 93 Review Regulatory T cells in rheumatoid arthritis Jan Leipe1 Alla Skapenko1 Peter E Lipsky2 and Hendrik Schulze-Koops1 2 1 Nikolaus Fiebiger Center for Molecular Medicine University of Erlangen-Nuremberg Erlangen Germany 2National Institute of Arthritis and Musculoskeletal and Skin Diseases National Institutes of Health Bethesda MD USA Corresponding author Hendrik Schulze-Koops schulze-koops@ Published 9 March 2005 This article is online at http content 7 3 93 2005 BioMed Central Ltd Arthritis Research Therapy 2005 7 93-99 DOI ar1718 Abstract Apart from the deletion of autoreactive T cells in the thymus various methods exist in the peripheral immune system to control specific human immune responses to self-antigens. One of these mechanisms involves regulatory T cells of which CD4 CD25 T cells are a major subset. Recent evidence suggests that CD4 CD25 T cells have a role in controlling the development of autoimmune diseases in animals and in humans. The precise delineation of the function of CD4 CD25 T cells in autoimmune inflammation is therefore of great importance for the understanding of the pathogenesis of autoimmune diseases. Moreover the ability to control such regulatory mechanisms might provide novel therapeutic opportunities in autoimmune disorders such as rheumatoid arthritis. Here we review existing knowledge of CD4 CD25 T cells and discuss their role in the pathogenesis of rheumatic diseases. Introduction The development of autoimmune diseases requires the breakdown of immunologic self-tolerance that usually controls self and non-self discrimination 1 . The primary mechanism that leads to tolerance to self-antigens is the thymic deletion of self-reactive T cells negative selection . However because some self-reactive T cells escape this process physiologically and autoreactive CD4 T cells are present in the peripheral circulation of .