tailieunhanh - Báo cáo y học: "THR0921, a novel peroxisome proliferator-activated receptor gamma agonist, reduces the severity of collagen-induced arthritis"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài:THR0921, a novel peroxisome proliferator-activated receptor gamma agonist, reduces the severity of collagen-induced arthritis. | Available online http content 8 1 R7 Open Access Research article THR0921 a novel peroxisome proliferator-activated receptor gamma agonist reduces the severity of collagen-induced arthritis Tetsuya Tomita Yoshimi Kakiuchi and Philip S Tsao Falk Cardiovascular Research Center Stanford University School of Medicine 300 Pasteur Drive Stanford CA 94305 USA Corresponding author Philip S Tsao ptsao@ Received 16 Mar 2005 Revisions requested 9 May 2005 Revisions received 16 Sep 2005 Accepted 20 Oct 2005 Published 17 Nov 2005 Arthritis Research Therapy 2006 8 R7 doi ar1856 This article is online at http content 8 1 R7 2005 Tomita et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract THR0921 is a novel peroxisome proliferator-activated receptor gamma PPARy agonist with potent anti-diabetic properties. Because of the proposed role of PPARy in inflammation we investigated the potential of orally active THR0921 to inhibit the pathogenesis of collagen-induced arthritis CIA . CIA was induced in DBA 1J mice by the injection of bovine type II collagen in complete Freund s adjuvant on days 0 and 21. Mice were treated with THR0921 50 mg kg day starting on the day of the booster injection and throughout the remaining study period. Both clinical disease activity scores as well as histological scores of joint destruction were significantly reduced in mice treated with THR0921 compared to untreated mice. Proliferation of isolated spleen cells as well as circulating levels of IgG antibody to type II collagen was decreased by THR0921. Moreover spleen cell production of IFN-Y tumor necrosis factor TNF -a and IL-1P in response to exposure to lipopolysaccharide or type II .