tailieunhanh - Báo cáo y học: "Anti-SSA/Ro antibodies and the heart: more than complete congenital heart block? A review of electrocardiographic and myocardial abnormalities and of treatment options"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Anti-SSA/Ro antibodies and the heart: more than complete congenital heart block? A review of electrocardiographic and myocardial abnormalities and of treatment options. | Available online http content 7 2 69 Review Anti-SSA Ro antibodies and the heart more than complete congenital heart block A review of electrocardiographic and myocardial abnormalities and of treatment options Nathalie Costedoat-Chalumeau1 Zahir Amoura1 Elisabeth Villain2 Laurence Cohen3 and Jean-Charles Piette1 Service de Médecine Interne Centre Hospitalier Universitaire Pitié-Salpêtrière Paris France 2Service de Cardiologie Pédiatrique Centre Hospitalier Universitaire Necker-Enfants Malades Paris France 3Service de Cardiologie Pédiatrique Institut Jacques Cartier Avenue du Noyer Lambert Massy France Corresponding author Nathalie Costedoat-Chalumeau Published 25 January 2005 Arthritis Res Ther 2005 7 69-73 DOI ar1690 2005 BioMed Central Ltd Abstract Apart from complete and incomplete congenital heart block CHB new cardiac manifestations related to anti-SSA Ro antibodies have been reported in children born to mothers bearing these antibodies. These manifestations include transient fetal first-degree heart block prolongation of corrected QT QTc interval sinus bradycardia late-onset cardiomyopathy endocardial fibroelastosis and cardiac malformations. Anti-SSA Ro antibodies are not considered pathogenic to the adult heart but a prolongation of the QTc interval has recently been reported in adult patients and is still a matter of debate. Treatment of CHB is not well established and needs to be assessed carefully. The risks and benefits of prenatal fluorinated steroids are discussed. Introduction Anti-SSA Ro antibodies have long been associated with an increased risk of fetal congenital heart block CHB . Apart from complete and incomplete CHB new cardiac manifestations related to anti-SSA Ro antibodies have been reported in children born to mothers bearing these antibodies. These manifestations include transient fetal first-degree heart block 1 prolongation of corrected QT QTc interval 2 3 sinus .