tailieunhanh - Báo cáo y học: "Soluble RAGE: a hot new biomarker for the hot joint"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Soluble RAGE: a hot new biomarker for the hot joint? | Arthritis Research Therapy August 2005 Vol 7 No 4 Moser et al. Commentary Soluble RAGE a hot new biomarker for the hot joint Bernhard Moser Barry I Hudson and Ann Marie Schmidt Department of Surgery College of Physicians and Surgeons Columbia University New York NY USA Corresponding author Ann Marie Schmidt ams11@ Published 3 June 2005 Arthritis Research Therapy 2005 7 142-144 DOI ar1764 This article is online at http content 7 4 142 2005 BioMed Central Ltd See related research by Pullerits et al. http content 7 4 R817 Abstract The receptor for advanced glycation endproducts RAGE interacts with distinct ligand families linked to the inflammatory response. Studies in animal models suggest that RAGE is upregulated in the inflamed joint and that blockade of the receptor using a ligand decoy soluble form of RAGE sRAGE attenuates joint inflammation and expression of inflammatory and tissuedestructive mediators. In this issue of Arthritis Research Therapy Rille Pullerits and colleagues reported that plasma levels of sRAGE were reduced in subjects with rheumatoid arthritis compared with healthy controls or subjects with non-inflammatory joint disease. These findings suggest the possibility that levels of sRAGE might be a biomarker of inflammation. Not resolved by these studies however is the intriguing possibility that endogenously higher levels of sRAGE might be linked to a lower incidence of arthritis or to the extent of inflammation. Nevertheless although cause or effect relationships may not be established in this report fascinating insights into RAGE inflammation and human arthritis emerge from these studies. Introduction In this issue of Arthritis Research Therapy Pullerits and colleagues 1 reported that plasma levels of soluble receptor for advanced glycation endproducts sRAGE were decreased in human subjects with rheumatoid arthritis RA compared to healthy normal subjects or subjects with .