tailieunhanh - Báo cáo y học: "Local IL-13 gene transfer prior to immune-complex arthritis inhibits chondrocyte death and matrix-metalloproteinase-mediated cartilage matrix degradation despite enhanced joint inflammation"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Local IL-13 gene transfer prior to immune-complex arthritis inhibits chondrocyte death and matrix-metalloproteinase-mediated cartilage matrix degradation despite enhanced joint inflammation. | Available online http content 7 2 R392 Research article Local IL-13 gene transfer prior to immune-complex arthritis inhibits chondrocyte death and matrix-metalloproteinase-mediated cartilage matrix degradation despite enhanced joint inflammation Karin CAM Nabbe1 Peter LEM van Lent1 Astrid EM Holthuysen1 Annet W Sloetjes1 Alisa E Koch2 Timothy RDJ Radstake1 and Wim B van den Berg1 Department of Experimental Rheumatology and Advanced Therapeutics University Medical Center Nijmegen Nijmegen The Netherlands 2University of Michigan Medical School Ann Arbor Michigan USA and Veterans Administration Ann Arbor Ann Arbor Michigan USA Corresponding author Peter LEM van Lent Received 29 Jul 2004 Revisions requested 24 Sep 2004 Revisions received 9 Dec 2004 Accepted 22 Dec 2004 Published 26 Jan 2005 Arthritis Res Ther 2005 7 R392-R401 DOI ar1502 2005 Nabbe et al. licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is cited. Open Access Abstract During immune-complex-mediated arthritis ICA severe cartilage destruction is mediated by Fcy receptors FcyRs mainly FcyRI cytokines . IL-1 and enzymes matrix metalloproteinases MMPs . IL-13 a T helper 2 Th2 cytokine abundantly found in synovial fluid of patients with rheumatoid arthritis has been shown to reduce joint inflammation and bone destruction during experimental arthritis. However the effect on severe cartilage destruction has not been studied in detail. We have now investigated the role of IL-13 in chondrocyte death and MMP-mediated cartilage damage during ICA. IL-13 was locally overexpressed in knee joints after injection of an adenovirus encoding IL-13 AxCAhIL-13 1 day before the onset of arthritis injection of AxCANI an empty adenoviral construct .

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