tailieunhanh - Báo cáo y học: "Infiltration of the synovial membrane with macrophage subsets and polymorphonuclear cells reflects global disease activity in spondyloarthropathy"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Infiltration of the synovial membrane with macrophage subsets and polymorphonuclear cells reflects global disease activity in spondyloarthropathy. | Available online http content 7 2 R359 Research article Infiltration of the synovial membrane with macrophage subsets and polymorphonuclear cells reflects global disease activity in spondyloarthropathy Dominique Baeten1 Elli Kruithof1 Leen De Rycke1 Anemieke M Boots2 Herman Mielants1 Eric M Veys1 and Filip De Keyser1 Department of Rheumatology Ghent University Hospital Ghent Belgium department of Pharmacology Organon NV Oss The Netherlands Corresponding author Dominique Baeten Received 15 Sep 2004 Revisions requested 8 Nov 2004 Revisions received 22 Nov 2004 Accepted 21 Dec 2004 Published 21 Jan 2005 Arthritis Res Ther 2005 7 R359-R369 DOI ar1501 2005 Baeten et al. licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is cited. Open Access Abstract Considering the relation between synovial inflammation and global disease activity in rheumatoid arthritis RA and the distinct but heterogeneous histology of spondyloarthropathy SpA synovitis the present study analyzed whether histopathological features of synovium reflect specific phenotypes and or global disease activity in SpA. Synovial biopsies obtained from 99 SpA and 86 RA patients with active knee synovitis were analyzed for 15 histological and immunohistochemical markers. Correlations with swollen joint count serum C-reactive protein concentrations and erythrocyte sedimentation rate were analyzed using classical and multiparameter statistics. SpA synovitis was characterized by higher vascularity and infiltration with CD163 macrophages and polymorphonuclear leukocytes PMNs and by lower values for lining-layer hyperplasia lymphoid aggregates CD1a cells intracellular citrullinated proteins and MHC-HC gp39 complexes than RA synovitis. .