tailieunhanh - Báo cáo y học: "NADPH-oxidase-driven oxygen radical production determines chondrocyte death and partly regulates metalloproteinase-mediated cartilage matrix degradation during interferon-γ-stimulated immune complex arthritis"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: NADPH-oxidase-driven oxygen radical production determines chondrocyte death and partly regulates metalloproteinase-mediated cartilage matrix degradation during interferon-γ-stimulated immune complex arthritis. | Available online http content 7 4 R885 Research article NADPH-oxidase-driven oxygen radical production determines chondrocyte death and partly regulates metalloproteinase-mediated cartilage matrix degradation during interferon-y-stimulated immune complex arthritis Peter LEM van Lent1 Karin CAM Nabbe1 Arjen B Blom1 Annet Sloetjes1 Astrid EM Holthuysen1 Jay Kolls2 Fons AJ Van De Loo1 Steven M Holland3 and Wim B Van Den Berg1 1Department of Rheumatology University Medical Centre St Radboud Nijmegen The Netherlands 2Department of Pediatrics University of Pittsburgh School of Medicine Pittsburgh PA USA 3Department of Host Defenses National Institute of Allergy and Infectious Diseases Bethesda MD USA Corresponding author Peter LEM van Lent Received 21 Jul 2004 Revisions requested 24 Sep 2004 Revisions received 5 Apr 2005 Accepted 19 Apr 2005 Published 20 May 2005 Arthritis Research Therapy 2005 7 R885-R895 DOI 86 ar1 760 This article is online at http content 7 4 R885 2005 van Lent et al. licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract In previous studies we have found that FcyRI determines chondrocyte death and matrix metalloproteinase MMP -mediated cartilage destruction during IFN-y-regulated immune complex arthritis ICA . Binding of immune complexes ICs to FcyRI leads to the prominent production of oxygen radicals. In the present study we investigated the contribution of NADPH-oxidase-driven oxygen radicals to cartilage destruction by using p47phox_ mice lacking a functional NADPH oxidase complex. Induction of a passive ICA in the knee joints of p47phox _ mice resulted in a significant elevation of joint inflammation at day 3 when