tailieunhanh - Báo cáo y học: "Tapasin gene polymorphism in systemic onset juvenile rheumatoid arthritis: a family-based case–control study"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài:Tapasin gene polymorphism in systemic onset juvenile rheumatoid arthritis: a family-based case–control study. | Available online http content 7 2 R285 Research article Tapasin gene polymorphism in systemic onset juvenile rheumatoid arthritis a family-based case-control study Hulya Bukulmez1 2 3 4 Mark Fife5 Monica Tsoras1 Susan D Thompson1 Natalie A Twine5 Patricia Woo5 Jane M Olson2 Robert C Elston2 David N Glass1 and Robert A Colbert1 Open Access 1William S. Rowe Division of Pediatric Rheumatology Cincinnati Children s Hospital Medical Center University of Cincinnati Cincinnati Ohio USA 2Department of Epidemiology and Biostatistics Case Western Reserve University Cleveland Ohio USA 3Department of Genetics Case Western Reserve University Cleveland Ohio USA 4Pediatric Rheumatology Pediatrics Metro Health Medical Center Case Western Reserve University Cleveland Ohio USA 5The Center for Pediatric and Adolescent Rheumatology University College London London UK Corresponding author Hulya Bukulmez hxb38@ Received 13 Mar 2004 Revisions requested 13 May 2004 Revisions received 17 Nov 2004 Accepted 22 Nov 2004 Published 11 Jan 2005 Arthritis Res Ther 2005 7 R285-R290 DOI ar1480 2005 Bukulmez et al. licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is cited. Abstract Juvenile rheumatoid arthritis JRA comprises a group of chronic systemic inflammatory disorders that primarily affect joints and can cause long-term disability. JRA is likely to be a complex genetic trait or a series of such traits with both genetic and environmental factors contributing to the risk for developing the disease and to its progression. The HLA region on the short arm of chromosome 6 has been intensively evaluated for genetic contributors to JRA and multiple associations and more recently linkage has been detected. Other genes involved in innate and