tailieunhanh - Báo cáo y học: "Gene expression profiling in murine autoimmune arthritis during the initiation and progression of joint inflammation"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài:Gene expression profiling in murine autoimmune arthritis during the initiation and progression of joint inflammation. | Available online http content 7 2 R196 Research article Gene expression profiling in murine autoimmune arthritis during the initiation and progression of joint inflammation Vyacheslav A Adarichev1 Csaba Vermes1 Anita Hanyecz1 Katalin Mikecz1 Eric G Bremer2 and Tibor T Glant1 Section of Biochemistry and Molecular Biology Department of Orthopedic Surgery Rush University Medical Center Chicago Illinois USA 2Children s Memorial Institute for Education and Research Northwestern University Chicago Illinois USA Corresponding author Tibor T Glant tglant@ Received 10 Aug 2004 Revisions requested 16 Sep 2004 Revisions received 4 Nov 2004 Accepted 10 Nov 2004 Published 14 Dec 2004 Arthritis Res Ther 2005 7 R196-R207 DOI ar1472 2004 Adarichev et al. licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract We present here an extensive study of differential gene expression in the initiation acute and chronic phases of murine autoimmune arthritis with the use of high-density oligonucleotide arrays interrogating the entire mouse genome. Arthritis was induced in severe combined immunodeficient mice by using adoptive transfer of lymphocytes from proteoglycan-immunized arthritic BALB c mice. In this unique system only proteoglycanspecific lymphocytes are transferred from arthritic mice into syngeneic immunodeficient recipients that lack adaptive immunity but have intact innate immunity on an identical BALB c genetic background. Differential gene expression in response to donor lymphocytes that migrated into the joint can therefore be monitored in a precisely timed manner even before the onset of inflammation. The initiation phase of adoptively transferred disease several days before the onset

TÀI LIỆU LIÊN QUAN
TỪ KHÓA LIÊN QUAN
crossorigin="anonymous">
Đã phát hiện trình chặn quảng cáo AdBlock
Trang web này phụ thuộc vào doanh thu từ số lần hiển thị quảng cáo để tồn tại. Vui lòng tắt trình chặn quảng cáo của bạn hoặc tạm dừng tính năng chặn quảng cáo cho trang web này.