tailieunhanh - Báo cáo y học: "Early and stable upregulation of collagen type II, collagen type I and YKL40 expression levels in cartilage during early experimental osteoarthritis occurs independent of joint location and histological grading"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài:Early and stable upregulation of collagen type II, collagen type I and YKL40 expression levels in cartilage during early experimental osteoarthritis occurs independent of joint location and histological grading. | Available online http content 7 1 R156 Research article Early and stable upregulation of collagen type II collagen type I and YKL40 expression levels in cartilage during early experimental osteoarthritis occurs independent of joint location and histological grading Helga Lorenz Wolfram Wenz Mate Ivancic Eric Steck and Wiltrud Richter Open Access Division of Experimental Orthopedics University of Heidelberg Germany Corresponding author Wiltrud Richter Received 20 Aug 2004 Revisions requested 13 Oct 2004 Revisions received 6 Nov 2004 Accepted 10 Nov 2004 Published 7 Dec 2004 Arthritis Res Ther 2005 7 R156-R165 DOI ar1471 2004 Lorenz et al. licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is cited. Abstract While morphologic and biochemical aspects of degenerative joint disease osteoarthritis OA have been elucidated by numerous studies the molecular mechanisms underlying the progressive loss of articular cartilage during OA development remain largely unknown. The main focus of the present study was to gain more insight into molecular changes during the very early stages of mechanically induced cartilage degeneration and to relate molecular alterations to histological changes at distinct localizations of the joint. Studies on human articular cartilage are hampered by the difficulty of obtaining normal tissue and early-stage OA tissue and they allow no progressive follow-up. An experimental OA model in dogs with a slow natural history of OA Pond-Nuki model was therefore chosen. Anterior cruciate ligament transection ACLT was performed on 24 skeletally mature dogs to induce joint instability resulting in OA. Samples were taken from different joint areas after 6 12 24 and 48 weeks .