tailieunhanh - Báo cáo y học: "Rheumatoid arthritis synovium contains plasmacytoid dendritic cells"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài:Rheumatoid arthritis synovium contains plasmacytoid dendritic cells. | Available online http content 7 2 R230 Research article Rheumatoid arthritis synovium contains plasmacytoid dendritic cells Lois L Cavanagh1 Amanda Boyce1 Louise Smith1 Jagadish Padmanabha1 Luis Filgueira2 Peter Pietschmann3 and Ranjeny Thomas1 Centre for Immunology and Cancer Research University of Queensland Princess Alexandra Hospital Brisbane Australia institute of Anatomy University Irchel-Zurich Zurich Switzerland 3Department of General and Experimental Pathology University of Vienna Vienna Austria Corresponding author Ranjeny Thomas rthomas@ Received 11 Jun 2004 Revisions requested 29 Jul 2004 Revisions received 13 Oct 2004 Accepted 26 Oct 2004 Published 11 Jan 2005 Arthritis Res Ther 2005 7 R230-R240 DOI ar1467 2004 Cavanagh et al. licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is cited. Open Access Abstract We have previously described enrichment of antigen-presenting HLA-DR nuclear RelB dendritic cells DCs in rheumatoid arthritis RA synovium. CD1 23 HLA-DR plasmacytoid DCs pDCs and their precursors have been identified in human peripheral blood PB lymphoid tissue and some inflamed tissues. We hypothesized recruitment of pDCs into the inflamed RA synovial environment and their contribution as antigenpresenting cells APCs and inflammatory cells in RA. CD11c myeloid DCs and CD1 23 pDCs were compared in normal and RA PB synovial fluid SF and synovial tissue by flow cytometry immunohistochemistry and electron microscopy and were sorted for functional studies. Nuclear RelB CD123 DCs were located in perivascular regions of RA in a similar frequency to Keywords dendritic cells plasmacytoid rheumatoid arthritis TNF nuclear RelB CD123- DCs but not normal synovial tissue sublining. Apart from .

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