tailieunhanh - Báo cáo y học: "Identification of a SmD3 epitope with a single symmetrical dimethylation of an arginine residue as a specific target of a subpopulation of anti-Sm antibodies"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài:Identification of a SmD3 epitope with a single symmetrical dimethylation of an arginine residue as a specific target of a subpopulation of anti-Sm antibodies. | Available online http content 7 1 R19 Research article Identification of a SmD3 epitope with a single symmetrical dimethylation of an arginine residue as a specific target of a subpopulation of anti-Sm antibodies Michael Mahler1 Marvin J Fritzler2 and Martin Bluthner3 Open Access Director Development and Production Dr. Fooke Laboratorien GmbH Neuss Germany 2Professor of Medicine Faculty of Medicine University of Calgary Calgary Canada 3Vice Director of Autoimmune Diagnostics Laboratory of Prof. Seelig and colleagues Karlsruhe Germany Corresponding author Michael Mahler Received 9 Aug 2004 Revisions requested 26 Aug 2004 Revisions received 31 Aug 2004 Accepted 1 Oct 2004 Published 1 0 Nov 2004 Arthritis Res Ther 2005 7 R19-R29 DOI ar1455 2004 Mahler et al. licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is cited. Abstract Anti-Sm antibodies identified in 1966 by Tan and Kunkel are highly specific serological markers for systemic lupus erythrematosus SLE . Anti-Sm reactivity is found in 5-30 of SLE patients depending on the autoantibody detection system and the racial background of the SLE population. The Sm autoantigen complex comprises at least nine different polypeptides. All of these core proteins can serve as targets of the anti-Sm B-cell response but most frequently the B and D polypeptides are involved. Because the BB Sm proteins share cross-reactive epitopes PPPGMRPP with U1 specific ribonucleoproteins which are more frequently targeted by antibodies that are present in patients with mixed connective tissue disease the SmD polypeptides are regarded as the Sm autoantigens that are most specific to SLE. It was recently shown that the polypeptides D1 D3 and BB contain symmetrical .