tailieunhanh - Báo cáo y học: "Elevated matrix metalloproteinase-9 in patients with systemic sclerosi"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài:Elevated matrix metalloproteinase-9 in patients with systemic sclerosis. | Available online http content 7 1 R71 Research article Elevated matrix metalloproteinase-9 in patients with systemic sclerosis Wan-Uk Kim So-Youn Min Mi-La Cho Kyung-Hee Hong Yong-Joo Shin Sung-Hwan Park and Chul-Soo Cho Division of Rheumatology Department of Internal Medicine Catholic Research Institutes of Medical Science School of Medicine The Catholic University of Korea Seoul Republic of Korea Corresponding author Chul-Soo Cho chocs@ Received 19 Mar 2004 Revisions requested 19 Apr 2004 Revisions received 23 Sep 2004 Accepted 1 Oct 2004 Published 1 0 Nov 2004 Arthritis Res Ther 2005 7 R71-R79 DOI ar1454 2004 Kim et al. licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is cited. Open Access Abstract Matrix metalloproteinase-9 MMP-9 has been implicated in the pathogenesis of cancer autoimmune disease and various pathologic conditions characterized by excessive fibrosis. In this study we investigated the expression of MMP-9 and its clinical significance in systemic sclerosis SSc . The patients n 42 with SSc had higher concentrations of MMP-9 and of tissue inhibitor of metalloproteinase-1 TIMP-1 and a higher ratio of MMP-9 to TIMP-1 in sera than healthy controls n 32 . Serum MMP-9 concentrations were significantly higher in the diffuse type n 23 than the limited type of SSc n 19 . Serum concentrations of MMP-9 correlated well with the degree of skin involvement as determined by the Rodnan score and with serum concentrations of transforming growth factor p. Moreover dermal fibroblasts from patients with SSc produced more MMP-9 than those from healthy controls when they were stimulated with IL-1p tumor necrosis factor a or transforming growth factor p. Such an increase in MMP-9 production was partially

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