tailieunhanh - Báo cáo y học: " Effects of disease modifying agents and dietary intervention on insulin resistance and dyslipidemia in inflammatory arthritis: a pilot study"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Effects of disease modifying agents and dietary intervention on insulin resistance and dyslipidemia in inflammatory arthritis: a pilot study. | Available online http 4 6 R12 Research article Effects of disease modifying agents and dietary intervention on insulin resistance and dyslipidemia in inflammatory arthritis a pilot study Patrick H Dessein1 Barry I Joffe2 and Anne E Stanwix1 1 Department of Rheumatology Johannesburg Hospital University of the Witwatersrand Johannesburg South Africa 2Centre for Diabetes and Endocrinology Johannesburg South Africa Corresponding author PH Dessein e-mail Dessein@ Received 26 June 2002 Revisions received 14 August 2002 Accepted 16 August 2002 Published 16 September 2002 Arthritis Res 2002 4 R12 DOI ar597 2002 Dessein et al. licensee BioMed Central Ltd Print ISSN 1465-9905 Online ISSN 1465-9913 Abstract Patients with rheumatoid arthritis RA experience excess cardiovascular disease CVD . We investigated the effects of disease-modifying antirheumatic drugs DMARD and dietary intervention on CVD risk in inflammatory arthritis. Twenty-two patients 17 women 15 with RA and seven with spondyloarthropathy who were insulin resistant n 20 as determined by the Homeostasis Model Assessment and or were dyslipidemic n 11 were identified. During the third month after initiation of DMARD therapy body weight C-reactive protein CRP insulin resistance and lipids were reevaluated. Results are expressed as median interquartile range . DMARD therapy together with dietary intervention was associated with weight loss of 4 kg kg a decrease in CRP of 14 6-36 P and a reduction in insulin Keywords cardiovascular risk diet DMARD inflammatory arthritis resistance of 36 26-61 P . Diet compliers n 15 experienced decreases of 10 0-20 and 3 0-9 in total and low-density lipoprotein cholesterol respectively as compared with increases of 9 6-20 P and 3 0-9 P in in diet noncompliers. Patients on methotrexate n 14 experienced a reduction in CRP of 27 mg l 6-83 mg l as compared with a decrease of 10 mg l mg l P in patients not on