tailieunhanh - Báo cáo y học: "Therapy of ankylosing spondylitis and other spondyloarthritides: α established medical treatment, anti-TNF-α therapy and other novel approaches"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Therapy of ankylosing spondylitis and other spondyloarthritides: α established medical treatment, anti-TNF-α therapy and other novel approaches. | Available online http content 4 5 307 Review Therapy of ankylosing spondylitis and other spondyloarthritides established medical treatment anti-TNF-a therapy and other novel approaches Juergen Braun1 and Joachim Sieper2 1Rheumazentrum Ruhrgebiet Herne Germany 2Department of Gastroenterology and Rheumatology Hospital Benjamin Franklin Free University Berlin Germany Corresponding author Juergen Braun e-mail Received 14 May 2002 Accepted 17 June 2002 Published 6 August 2002 Arthritis Res 2002 4 307-321 2002 BioMed Central Ltd Print ISSN 1465-9905 Online ISSN 1465-9913 Abstract Therapeutic options for patients with more severe forms of spondyloarthritis SpA have been rather limited in recent decades. There is accumulating evidence that anti-tumor-necrosis-factor anti-TNF therapy is highly effective in SpA especially in ankylosing spondylitis and psoriatic arthritis. The major anti-TNF-a agents currently available infliximab Remicade and etanercept Enbrel are approved for the treatment of rheumatoid arthritis RA in many countries. In ankylosing spondylitis there is an unmet medical need since there are almost no disease-modifying antirheumatic drugs DMARDs available for severely affected patients especially those with spinal manifestations. Judging from recent data from more than 300 patients with SpA anti-TNF therapy seems to be even more effective in SpA than in rheumatoid arthritis. However it remains to be shown whether patients benefit from long-term treatment whether radiological progression and ankylosis can be stopped and whether long-term biologic therapy is safe. Keywords ankylosing spondylitis anti-TNF-a therapy conventional and innovative treatment psoriatic arthritis Introduction The spondyloarthritides SpAs comprise five subtypes ankylosing spondylitis AS reactive arthritis major parts of the arthritis spondylitis spectrum associated with psoriasis psoriatic arthritis PsA and inflammatory bowel .