tailieunhanh - Báo cáo y học: " Genetic epidemiology Juvenile idiopathic arthritis genetics – What’s new? What’s next"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Genetic epidemiology Juvenile idiopathic arthritis genetics – What’s new? What’s next? | Arthritis Research Vol 4 No 5 Thomson and Donn Review Genetic epidemiology Juvenile idiopathic arthritis genetics - What s new What s next Wendy Thomson and Rachelle Donn Arthritis Research Campaign Epidemiology Unit School of Epidemiology and Health Sciences University of Manchester Stopford Building Oxford Road Manchester M13 9PT UK Corresponding author Wendy Thomson e-mail wendy@ Received 19 April 2002 Revisions received 20 June 2002 Accepted 25 June 2002 Published 5 August 2002 Arthritis Res 2002 4 302-306 2002 BioMed Central Ltd Print ISSN 1465-9905 Online ISSN 1465-9913 Abstract Studies have established the magnitude of the genetic basis of juvenile idiopathic arthritis JIA . JIA is a complex genetic condition and the genes that influence susceptibility are actively being sought. A candidate gene approach is being used by several groups. MHC- cytokine- and T-cell-related genes have all been positively associated with JIA. Here we review some of the latest genetic data and discuss ways in which JIA genetic research might proceed. Keywords candidate genes cytokines genetics juvenile idiopathic arthritis Introduction It is necessary to define the genetic component of any disease in order to enhance the understanding of its pathogenesis imply its aetiology and refine its treatment. The most rapid progress towards such aims is best achieved when there is homology of the expressed form phenotype . Unfortunately progress in defining the genetic components of childhood arthritis has long proven difficult for two reasons. Firstly childhood inflammatory arthritis is not a single disease but a group of clinical syndromes. Secondly since its first description in the late 1890s classification of the chronic arthritides of childhood has been problematic. Ansell and Bywaters 1 first proposed that classification should be based on the characteristics of disease at onset and this basic premise still remains. This premise has led to the development of two .