tailieunhanh - Báo cáo y học: "Regulation of CD154-induced interleukin-12 production in synovial fluid macrophage"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Regulation of CD154-induced interleukin-12 production in synovial fluid macrophages. | Available online http 4 5 R9 Research article Regulation of CD154-induced interleukin-12 production in synovial fluid macrophages Milja Mottonen1 2 Pia Isomaki2 Reijo Luukkainen3 and Olli Lassila1 2 1Turku Graduate School of Biomedical Sciences Turku University Turku Finland 2Department of Medical Microbiology Turku University Turku Finland 3Satalinna Hospital Harjavalta Finland Corresponding author Milja Mottonen e-mail Received 12 March 2002 Revisions received 20 June 2002 Accepted 1 July 2002 Published 26 July 2002 Arthritis Res 2002 4 R9 2002 Mottonen et al. licensee BioMed Central Ltd Print ISSN 1465-9905 Online ISSN 1465-9913 Abstract Interleukin IL -12 being a major cytokine that induces T helper Th 1 differentiation and inflammatory response has been postulated to be an important mediator of synovial inflammation in rheumatoid arthritis RA . However the regulation of IL-12 production in RA has not been elucidated. Our knowledge is mainly based on studies of the production of IL-12p40 and not the functional IL-12p70 heterodimer. We have studied the CD154-induced IL-12p40 and IL-12p70 production by synovial fluid SF macrophages from patients with RA. CD40 ligation induced the secretion of IL-12p40 but not IL-12p70. The observed increase in IL-10 and tumor necrosis factor TNF -a production indicated that SF macrophages responded Keywords CD40 cytokines IL-12 rheumatoid arthritis to CD40 ligation. The expression of p40 mRNA was increased significantly and remained upregulated after CD40 ligation whereas the increase of p35 transcript expression was observed only transiently and at a lower level. We further observed that dendritic cells DCs derived in vitro from SF macrophages produced IL-12p70. Most importantly IL-4 and IL-13 primed SF macrophages to produce IL-12p70 whereas IFN-y was not observed to activate IL-12p70 production in these cells in contrast with normal peripheral blood monocytes. These results provide

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