tailieunhanh - Báo cáo y học: "Lack of autoantibody production associated with cytomegalovirus infection"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Lack of autoantibody production associated with cytomegalovirus infection. | Available online http 4 5 R6 Research article Lack of autoantibody production associated with cytomegalovirus infection Beth C Marshall1 Richard A McPherson2 Eric Greidinger3 Robert Hoffman3 and Stuart P Adler1 1 Department of Pediatrics Virginia Commonwealth University Medical College of Virginia Richmond Virginia USA 2Department of Pathology Virginia Commonwealth University Medical College of Virginia Richmond Virginia USA 3Department of Internal Medicine University of Missouri Columbia Missouri USA Corresponding author Stuart P Adler e-mail sadler@ Received 21 March 2002 Revisions received 2 May 2002 Accepted 20 May 2002 Published 20 June 2002 Arthritis Res 2002 4 R6 2002 Marshall et al. licensee BioMed Central Ltd Print ISSN 1465-9905 Online ISSN 1465-9913 Abstract To confirm an association between cytomegalovirus CMV infection and the presence of antibodies to Smith Sm to ribonucleoprotein RNP and to a component of the U1 ribonucleoproteins U1-70kD we measured antibodies to these protein antigens using an enzyme immunoassay and an immunoblot. The antibodies were measured in the sera of 80 healthy subjects one-half of whom were naturally CMV seropositive and one-half were CMV seronegative and in eight subjects immunized with a live attenuated strain of CMV. None of the vaccinees developed antibodies to Sm to RNP or to U1-70kD at either 4 or 12 months after immunization. Additionally there was no statistically significant association between levels of antibodies to Sm or to RNP and between sera obtained from vaccinees natural CMV seropositive individuals and CMV seronegative individuals. One CMV seropositive serum and one CMV seronegative serum tested positive for antibodies to U1-70kD. These data indicate that neither wild-type infection nor the live-attenuated Towne vaccine frequently induce autoantibody production. Keywords autoantibodies cytomegalovirus RNP antigen Sm antigen U1-70kD Introduction Antecedent infection with .