tailieunhanh - Báo cáo y học: "Cardiovascular risk in rheumatoid arthritis versus osteoarthritis: acute phase response related decreased insulin sensitivity and high-density lipoprotein cholesterol as well as clustering of metabolic syndrome features in rheumatoid arthritis"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Cardiovascular risk in rheumatoid arthritis versus osteoarthritis: acute phase response related decreased insulin sensitivity and high-density lipoprotein cholesterol as well as clustering of metabolic syndrome features in rheumatoid arthritis. | Available online http 4 5 R5 Research article Cardiovascular risk in rheumatoid arthritis versus osteoarthritis acute phase response related decreased insulin sensitivity and high-density lipoprotein cholesterol as well as clustering of metabolic syndrome features in rheumatoid arthritis Patrick H Dessein 1 Anne E Stanwix1 and Barry I Joffe2 1 Department of Rheumatology Johannesburg Hospital University of the Witwatersrand Johannesburg South Africa 2Centre for Diabetes and Endocrinology Johannesburg South Africa Corresponding author Patrick H Dessein e-mail Dessein@ Received 30 January 2002 Revisions received 19 April 2002 Accepted 16 May 2002 Published 19 June 2002 Arthritis Res 2002 4 R5 2002 Dessein et al. licensee BioMed Central Ltd Print ISSN 1465-9905 Online ISSN 1465-9913 Abstract Rheumatoid arthritis RA patients experience a markedly increased frequency of cardiovascular disease. We evaluated cardiovascular risk profiles in 79 RA patients and in 39 age-matched and sex-matched osteoarthritis OA patients. Laboratory tests comprised ultrasensitive C-reactive protein CRP and fasting lipids. Insulin sensitivity IS was determined by the Quantitative Insulin Sensitivity Check Index QUICKI in all OA patients and in 39 of the RA patients. Ten RA patients were on glucocorticoids. RA patients exercised more frequently than OA patients x2 P . Nine RA patients and one OA patient had diabetes x2 P . The median CRP the mean QUICKI and the mean high-density lipoprotein HDL cholesterol were 9 mg l range mg l 95 confidence interval CI and mmol l 95 CI mmol l in RA patients respectively as compared with mg l range mg l 95 CI and mmol l 95 CI mmol l in OA patients. Each of these differences was significant P . After controlling for the CRP the QUICKI was similar in RA and OA patients P while the differences in HDL cholesterol .