tailieunhanh - Báo cáo khoa học: "The combination effect of sodium butyrate and 5-Aza-2'-deoxycytidine on radiosensitivity in RKO colorectal cancer and MCF-7 breast cancer cell lines"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: The combination effect of sodium butyrate and 5-Aza-2'-deoxycytidine on radiosensitivity in RKO colorectal cancer and MCF-7 breast cancer cell lines | World Journal of Surgical Oncology BioMed Central Open Access The combination effect of sodium butyrate and 5-Aza-2 -deoxycytidine on radiosensitivity in RKO colorectal cancer and MCF-7 breast cancer cell lines Hang Joo Cho1 Sin Young Kim1 Kee Hwan Kim1 Won Kyung Kang2 Ji Il kim1 SeongTack Oh2 Jeong Soo Kim1 and Chang Hyeok An 1 Address Department of Surgery Uijongbu St Mary s Hospital College of Medicine The Catholic University of Korea South Korea and 2Department of Surgery Kangnam St Mary s Hospital College of Medicine The Catholic University of Korea South Korea Email Hang Joo Cho - surgeryman@ Sin Young Kim - shinn81@ Kee Hwan Kim - keehwan@ Won Kyung Kang - wonkkang@ Ji Il kim - cmckji@ SeongTack Oh - stoh@ Jeong Soo Kim - drbreast@ Chang Hyeok An - achcolo@ Corresponding author Published 21 May 2009 Received 30 March 2009 World Journal of Surgical Oncology 2009 7 49 doi l477-78l 9-7-49 Accepted 21 May 2009 This article is available from http content 7 l 49 2009 Cho et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background The overall level of chromatin compaction is an important mechanism of radiosensitivity and modification of DNA methylation and histone deacetylation may increase radiosensitivity by altering chromatin compaction. In this study we investigated the effect of a demethylating agent a histone deacetylase HDAC inhibitor and the two agents combined on radiosensitivity in human colon and breast cancer cell lines. Methods In this study we used RKO colorectal cancer cell line and MCF-7 breast cancer cell lines and normal colon cell lines. On each of the cell lines we