tailieunhanh - Báo cáo khoa học: "Genomic and oncoproteomic advances in detection and treatment of colorectal cancer"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Genomic and oncoproteomic advances in detection and treatment of colorectal cancer | BioMed Central World Journal of Surgical Oncology Open Access Review Genomic and oncoproteomic advances in detection and treatment of colorectal cancer Seamus M McHugh Jill O Donnell and Peter Gillen Address Dept. of Surgery Our Lady of Lourdes Hospital Drogheda County Louth Ireland Email Seamus M McHugh - seamusmchugh@ Jill O Donnell - jillodon@ Peter Gillen - pgillen@ Corresponding author Published I April 2009 World Journal of Surgical Oncology 2009 7 36 doi 1477-7819-7-36 Received II January 2009 Accepted I April 2009 This article is available from http content 7 1 36 2009 McHugh et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Aims We will examine the latest advances in genomic and proteomic laboratory technology. Through an extensive literature review we aim to critically appraise those studies which have utilized these latest technologies and ascertain their potential to identify clinically useful biomarkers. Methods An extensive review of the literature was carried out in both online medical journals and through the Royal College of Surgeons in Ireland library. Results Laboratory technology has advanced in the fields of genomics and oncoproteomics. Gene expression profiling with DNA microarray technology has allowed us to begin genetic profiling of colorectal cancer tissue. The response to chemotherapy can differ amongst individual tumors. For the first time researchers have begun to isolate and identify the genes responsible. New laboratory techniques allow us to isolate proteins preferentially expressed in colorectal cancer tissue. This could potentially lead to identification of a clinically useful protein biomarker in colorectal cancer screening and .