tailieunhanh - Báo cáo khoa học: "Lymphangiosis carcinomatosa in squamous cell carcinomas of larynx and hypopharynx – value of conventional evaluation and additional immunohistochemical staining of D2-40"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Lymphangiosis carcinomatosa in squamous cell carcinomas of larynx and hypopharynx – value of conventional evaluation and additional immunohistochemical staining of D2-40 | BioMed Central World Journal of Surgical Oncology Open Access Lymphangiosis carcinomatosa in squamous cell carcinomas of larynx and hypopharynx - value of conventional evaluation and additional immunohistochemical staining of D2-40 Hans-Ullrich Volker 1 Matthias Scheich2 Isabell Nowack2 Alexandra Metzger1 Imme Haubitz1 Bernhard Puppe1 Rudolf Hagen2 Hans-Konrad Muller-Hermelink1 and Christiane Volter2 Address institute of Pathology University of Wurzburg Germany and 2Dept. of Otorhinolaryngology University of Wurzburg Germany Email Hans-Ullrich Volker - Matthias Scheich - Isabell Nowack - Alexandra Metzger - Imme Haubitz - Bernhard Puppe - Rudolf Hagen - Hans-Konrad Muller-Hermelink - path062@ Christiane Volter - Voelter_C@ Corresponding author Published 4 March 2009 Received 12 November 2008 World Journal of Surgical Oncology 2009 7 25 doi l477-78l 9-7-25 Accepted 4 March 2009 This article is available from http content 7 l 25 2009 Volker et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Recent studies revealed a predictive value of lymphatic vessel invasion Ll for the nodal metastasizing and poor prognosis in malignant tumors at different sites. The monoclonal antibody D2-40 podoplanin stains specifically endothelial cells of lymphatic vessels and improves the search for Ll. However the importance of this immunohistochemical staining was not investigated in squamous cell carcinomas SCC of larynx and hypopharynx. Aim This study was performed to compare the .