tailieunhanh - Báo cáo y học: "Successful immunotherapy with matrix metalloproteinasederived peptides in adjuvant arthritis depends on the timing of peptide administration"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Successful immunotherapy with matrix metalloproteinasederived peptides in adjuvant arthritis depends on the timing of peptide administration. | Available online http 4 4 R2 Research article Successful immunotherapy with matrix metalloproteinase-derived peptides in adjuvant arthritis depends on the timing of peptide administration Jolanda HM van Bilsen Josée PA Wagenaar-Hilbers Maarten JF van der Cammen Mariska EA van Dijk Willem van Eden and Marca HM Wauben Department of Infectious Diseases and Immunology Faculty of Veterinary Medicine Utrecht University The Netherlands Corresponding author Marca HM Wauben e-mail Received 20 November 2001 Revisions received 13 March 2002 Accepted 10 April 2002 Published 7 May 2002 Arthritis Res 2002 4 R2 2002 van Bilsen et al. licensee BioMed Central Ltd Print ISSN 1465-9905 Online ISSN 1465-9913 Abstract We have recently found that matrix metalloproteinases MMPs are targets for T-cell and B-cell reactivity in experimental arthritis. In the present article we investigate whether modulation of MMP-specific T-cell responses could influence the course of adjuvant arthritis AA . Lewis rats were treated nasally with MMP peptides prior to or after AA induction. Administration of the MMP-10 or the MMP-16 peptide prior to AA induction reduced the arthritic symptoms. In contrast administration of the MMP-10 peptide after AA induction aggravated the arthritic symptoms. The present study shows the possible usefulness of MMP peptides for immunotherapy. However a clear understanding of proper timing of peptide administration is crucial for the development of such therapies. Keywords adjuvant arthritis immunotherapy matrix metalloproteinase nasal treatment peptides Introduction Rheumatoid arthritis RA is an autoimmune disease in which autoreactive T cells are considered to play a central role in the autodestructive process 1 2 . For the development of long-term acting antigen-specific immunotherapies considerable attention has been devoted to intervening in the autoimmune process via modulation of the autoaggressive T-cell response. Several .