tailieunhanh - Báo cáo y học: "Homing chemokines in rheumatoid arthritis"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Homing chemokines in rheumatoid arthritis. | Available online http content 4 4 233 Commentary Homing chemokines in rheumatoid arthritis Pius Loetscher and Bernhard Moser Theodor-Kocher Institute University of Bern Switzerland Corresponding author Pius Loetscher e-mail Received 17 December 2001 Accepted 15 January 2002 Published 31 January 2002 Arthritis Res 2002 4 233-236 2002 BioMed Central Ltd Print ISSN 1465-9905 Online ISSN 1465-9913 Abstract In about 20 of patients with rheumatoid arthritis B and T lymphocytes recruited into the inflamed synovium are organized into complex microstructures which resemble secondary lymphoid organs. The development of such lymphoid aggregates with germinal centers appears to contribute to the pathogenesis of the disease. Growing evidence indicates that chemokines and their receptors control the recruitment and positioning of leukocytes as well as their organization into node-like lymphoid structures. Here we comment on recent studies highlighting the importance of chemokines in rheumatoid arthritis in particular of B-cell-activating chemokine-1 in lymphoid neogenesis in the inflamed synovium. Keywords BCA-1 chemokine receptors chemokines CXCR5 ectopic follicles Introduction Rheumatoid arthritis RA is an autoimmune disease characterized by chronic inflammation and destruction of the cartilage and bone in the joints 1 . Despite the large research effort neither the initiating event nor the perpetuating factors are clearly understood. The characteristic features of the disease are synovial lining hyperplasia and chronic infiltration of inflammatory cells including T lymphocytes B lymphocytes monocytes macrophages and granulocytes. The hyperplastic lining layer is mainly composed of highly activated macrophage-like cells and proliferating fibroblast-like cells. The infiltrating lymphocytes are localized in the sublining tissue and are found around the blood vessels and in the stroma. Frequently lymph-node-like aggregates are .

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