tailieunhanh - Báo cáo y học: "Transcriptional regulation of collagenase (MMP-1, MMP-13) genes in arthritis: integration of complex signaling pathways for the recruitment of gene-specific transcription factor"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Transcriptional regulation of collagenase (MMP-1, MMP-13) genes in arthritis: integration of complex signaling pathways for the recruitment of gene-specific transcription factors. | Available online http content 4 3 157 Review Transcriptional regulation of collagenase MMP-1 MMP-13 genes in arthritis integration of complex signaling pathways for the recruitment of gene-specific transcription factors Matthew P Vincenti1 and Constance E Brinckerhoff1 2 1 Department of Medicine Dartmouth Medical School Hanover New Hampshire USA 2Department of Biochemistry Dartmouth Medical School Hanover New Hampshire USA Correspondence Matthew P Vincenti Department of Medicine Dartmouth Medical School Hanover New Hampshire 03755 USA. Tel 1 603 650 1607 fax 1 603 650 1128 e-mail mpv@ Received 31 August 2001 Revisions requested 5 October 2001 Revisions received 2 November 2001 Accepted 9 November 2001 Published 23 November 2001 Arthritis Res 2002 4 157-164 2002 BioMed Central Ltd Print ISSN 1465-9905 Online ISSN 1465-9913 Abstract Matrix metalloproteinase MMP -1 MMP-8 and MMP-13 are interstitial collagenases that degrade type II collagen in cartilage this is a committed step in the progression of rheumatoid arthritis and osteoarthritis. Of these enzymes the expression of MMP-1 and MMP-13 is substantially increased in response to IL-1 and tumor necrosis factor-a and elevated levels of these collagenases are observed in arthritic tissues. Therefore cytokine-mediated MMP-1 and MMP-13 gene regulation is an important issue in arthritis research. In this review we discuss current models of MMP-1 and MMP-13 transcriptional regulation with a focus on signaling intermediates and transcription factors that may be future targets for the development of new arthritis drugs. Keywords arthritis matrix metalloproteinases mitogen-activated protein kinases nuclear factor kB transcription. Introduction The matrix metalloproteinase MMP family members are the major enzymes that degrade the components of the extracellular matrix 1 2 . At the time of writing this article 20 members of this family have been identified 3 . All are active at neutral pH .