tailieunhanh - Báo cáo khoa học: "Cell cyclins: triggering elements of cancer or not?"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Cell cyclins: triggering elements of cancer or not? | Stamatakos et al. World Journal of Surgical Oncology 2010 8 111 http content 8 1 111 5 2 WORLD JOURNAL OF SURGICAL ONCOLOGY REVIEW Open Access Cell cyclins triggering elements of cancer or not 1 1 2 3 4 Michael Stamatakos Victoria Palla Ioannis Karaiskos Konstantinos Xiromeritis Ioannis Alexiou Ioannis Pateras2 Konstantinos Kontzoglou4 Abstract Cyclins are indispensable elements of the cell cycle and derangement of their function can lead to cancer formation. Recent studies have also revealed more mechanisms through which cyclins can express their oncogenic potential. This review focuses on the aberrant expression of G1 S cyclins and especially cyclin D and cyclin E the pathways through which they lead to tumour formation and their involvement in different types of cancer. These elements indicate the mechanisms that could act as targets for cancer therapy. Introduction Cyclins are proteins which act as key controlling elements of the eukaryotic cell cycle. These proteins have some regions of homology such as the cyclin box and some other islands of homology outside the cyclin box 1 . In mammalian cells cyclins bind to cyclin dependent kinases and form complexes that are involved in regulating different cell cycle transitions cyclin-D-CDK4 6 complex for G1 progression cyclin- E - CDK2 for the G1-S transition cyclin-A-CDK2 for S phase progression and cyclin A B-CDC2 for entry into M-phase. In addition to these functions cyclins are also involved in some processes not directly related to the cell cycle. The importance of cyclin-CDK complexes in cell proliferation is underscored by the fact that deregulation in the function of these complexes is found in virtually the whole spectrum of human tumors and this comes from the fact that tumor-associated alterations in cyclins help to sustain proliferation independently of external mitogenic or anti-mitogenic signals 2 . In this review we are going to deal with the role of cyclins D and E in the development of .

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