tailieunhanh - Báo cáo khoa học: "Does Doxycycline work in synergy with cisplatin and oxaliplatin in colorectal cancer?"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Does Doxycycline work in synergy with cisplatin and oxaliplatin in colorectal cancer? | BioMed Central World Journal of Surgical Oncology Research Does Doxycycline work in synergy with cisplatin and oxaliplatin in colorectal cancer Jayesh Sagar 1 2 Kevin Sales1 Sas Dijk1 JanWillem Taanman3 Alexander Seifalian2 and Mark Winslet1 2 Address 1Division of Surgery and Interventional Science University College London Gower Street London WC1E 6BT UK 2Academic Department of Surgery Royal Free University College Medical School Pond Street London NW3 2QG UK and 3Department of Clinical Neuroscience Royal Free University College Medical School Pond Street London NW3 2QG UK Email Jayesh Sagar - jsagar_2001@ Kevin Sales - Sas Dijk - JanWillem Taanman - Alexander Seifalian - Mark Winslet - Corresponding author Open Access Published 6 January 2009 Received 16 May 2008 World Journal of Surgical Oncology 2009 7 2 doi l477-78l9-7-2 Accepted 6 January 2009 This article is available from http content 7 l 2 2009 Sagar et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract_ Background In recent years apart from antibacterial properties doxycycline is reported to have cytotoxic and anti-proliferative actions in various cancers including colorectal cancer. Colorectal cancer constitutes one of the most common cancers in the western population. Apart from surgery chemotherapy plays crucial role in the treatment of colorectal cancer. Cisplatin and oxaliplatin are most commonly used platinum compounds for the cancer chemotherapy. This study has looked for any impact of doxycycline on the .