tailieunhanh - Dipeptidyl Aminopeptidases Basic Science and Clinical Applications

DPP IV has been attributed a large array of functions, some of which are mediated by its exopeptidase activity. Although it only removes two amino acid residues at the N-terminus of the peptide, this cleavage can inactivate or modify the activity of regulatory peptides, peptide hormones, chemokines and neuropeptides. Several excellent DPP IV substrates with high specificity constants were identified by the in vitro kinetic study of the truncation of bioactive peptides by DPP IV. In vivo studies . with DPP IV negative animals and in vivo inhibition experiments could enlighten us on the physiological relevance of these truncations. The DPP IV mediated truncation of bioactive peptides. | ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY Volume 575 DIPEPTIDYL AMINOPEPTIDASES Basic Science and Clinical Applications Edited by Uwe Lendeckel Dirk Reinhold and Ute Bank Springer Uwe Lendeckel Dirk Reinhold Ute Bank Editors Dipeptidyl Aminopeptidases Basic Science and Clinical Applications With 77 Figures iii Uwe Lendeckel Dirk Reinhold Ute Bank Otto-von-Guericke University Magdeburg Germany Library of Congress Control Number 2006920031 ISBN 10 0-387-29058-3 e-ISBN 0-387-32824-6 ISBN 13 978-0387-29058-4 Printed on acid-free paper. 2006 Springer Science Business Media Inc. All rights reserved. This work may not be translated or copied in whole or in part without the written permission of the publisher Springer Science Business Media Inc. 233 Spring Street New York NY 10013 USA except for brief excerpts in connection with reviews or scholarly analysis. Use in connection with any form of information storage and retrieval electronic adaptation computer software or by similar or dissimilar methodology now known or hereafter developed is forbidden. The use in this publication of trade names trademarks service marks and similar terms even if they are not identified as such is not to be taken as an expression of opinion as to whether or not they are subject to proprietary rights. Printed in the United States of America. TB MVY 987654321 .