tailieunhanh - Báo cáo khoa học: "Identification of a novel germ-line mutation in the TP53 gene in a Mexican family with Li-Fraumeni syndrome"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Identification of a novel germ-line mutation in the TP53 gene in a Mexican family with Li-Fraumeni syndrome | World Journal of Surgical Oncology BioMed Central Open Access Identification of a novel germ-line mutation in the TP53 gene in a Mexican family with Li-Fraumeni syndrome Lucia Taja-Chayeb 11 Silvia Vidal-Millan11 Olga Gutierrez-Hernandez1 Catalina Trejo-Becerril1 Enrique Pérez-Cárdenas1 Alma Chavez-Blanco1 Erick de la Cruz-Hernandez1 and Alfonso Duenas-Gonzalez1 2 Address 1Instituto Nacional de Cancerología INCan Mexico City Mexico and 2Unidad de Investigación Biomédica en Cancer Instituto de Investigaciones Biomédicas IIB Universidad Nacional Autónoma de Mexico UNAM Mexico City Mexico Email Lucia Taja-Chayeb - ltaja_chayeb@ Silvia Vidal-Millan - vidals02@ Olga Gutierrez- Hernandez - olgagut76@ CatalinaTrejo-Becerril - ctrejobecerril@ Enrique Perez- Cardenas - zeferinoenrique_1999@ Alma Chavez-Blanco - celular_alma@ Erick de la Cruz- Hernandez - qcerick2000@ Alfonso Duenas-Gonzalez - alfonso_duenasg@ Corresponding author fEqual contributors Published 17 December 2009 Received 31 August 2009 _ r. nno I Accepted 17 December 2009 World Journal of Surgical Oncology 2009 7 97 doi l477-78l 9-7-97 This article is available from http content 7 l 97 2009 Taja-Chayeb et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Germ-line mutations of the TP53 gene are known to cause Li-Fraumeni syndrome an autosomal dominantly inherited high-penetrance cancer-predisposition syndrome characterized by the occurrence of a variety of cancers mainly soft tissue sarcomas adrenocortical carcinoma leukemia breast cancer and brain tumors. Methods Mutation analysis was based on Denaturing high performance liquid .