tailieunhanh - Progestins and the Mammary Gland From Basic Science to Clinical Applications

Steroid hormone receptors are important drug targets and have been the focus of basic and applied research for decades. Steroid hormone receptors act as ligand-dependent transcription factors. Upon ligand binding, the receptors bind to hormone responsive cis-acting DNA elements (HREs) in the nucleus and regulate the expression of target genes by recruiting chromatin-modifying activities that either promote or deny access to the basal transcription machinery. In general, agonist ligands recruit coactivator proteins that promote transcriptional activation, while receptor antagonists recruit corepressors that prevent transcriptional activation | fi ernst Schering foundation Progestins and the Mammary Gland From Basic Science to Clinical Applications Symposium Proceedings Editors I Springer Ernst Schering Foundation Symposium Proceedings 2007-1 Progestins and the Mammary Gland Ernst Schering Foundation Symposium Proceedings 2007-1 Progestins and the Mammary Gland From Basic Science to Clinical Applications O. Conneely C. Otto Editors With 43 Figures .

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