tailieunhanh - Báo cáo khoa học: "Impact of neoadjuvant treatment on total mesorectal excision for ultra-low rectal cancers"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Impact of neoadjuvant treatment on total mesorectal excision for ultra-low rectal cancers | Lim et al. World Journal of Surgical Oncology 2010 8 23 http content 8 1 23 WORLD JOURNAL OF SURGICAL ONCOLOGY RESEARCH Open Access Impact of neoadjuvant treatment on total mesorectal excision for ultra-low rectal cancers Yon Kuei Lim1 Wai Lun Law1 Rico Liu2 Jensen TC Poon1 Joe FM Fan1 Oswens SH Lo1 Abstract Background This study reviewed the impact of pre-operative chemoradiotherapy or post-operative chemotherapy and or radiotherapy on total mesorectal excision TME for ultralow rectal cancers that required either low anterior resection with peranal coloanal anastomosis or abdomino-perineal resection APR . We examined surgical complications local recurrence and survival. Methods Of the 1270 patients who underwent radical resection for rectal cancer from 1994 till 2007 180 with tumors within 4 cm with either peranal coloanal anastomosis or APR were analyzed. Patients were compared in groups that had surgery only Group A pre-operative chemoradiotherapy Group B and post-operative therapy Group C . Results There were 115 males and the mean age was years range 30-89 . APR was performed in 134 patients while 46 had a sphincter-preserving resection with peranal coloanal anastomosis. The mean follow-up period was months range to . There were 69 58 and 53 patients in Groups A B and C respectively. Nine patients in Group B could go on to have sphincter-saving rectal resection. The overall perioperative complication rate was in Group A vs. in Group B vs. in Group C respectively. The local recurrence rate was significantly lower in Group B vs. in Group A vs. in Group C p . The 5-year cancer-specific survival rates for Group A was Group B was and Group C was p . Conclusion Pre-operative chemoradiation in low rectal cancer is not associated with a higher incidence of perioperative complications and its benefits may include reduction local recurrence. Background In rectal cancer surgery .