tailieunhanh - Báo cáo khoa học: "Mixed germ cell tumor metastatic to the skin: Case report and literature review"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Mixed germ cell tumor metastatic to the skin: Case report and literature review | Chuang et al. World Journal of Surgical Oncology 2010 8 21 http content 8 1 21 WORLD JOURNAL OF SURGICAL ONCOLOGY CASE REPORT Open Access Mixed germ cell tumor metastatic to the skin Case report and literature review 3 4 2 1 1 Kun-Lung Chuang Chaung-Chi Liaw Shir Hwa Ueng Shuen-Kuei Liao See-Tong Pang Ying-Hsu Chang Heng-Chang Chuang 1 Cheng-Keng Chuang1 2 Abstract Background Testicular cancer is the most common cancer for males aged 15 35 years old. The initial presentation is typically an asymptomatic enlarged testicle. The retroperitoneum is the most common metastatic area. Other metastatic sites include the lung liver brain adrenal glands gastrointestinal tract and spleen. Skin metastasis is a rare event and frequently associated with poor prognosis. Case presentation A 19-year old male was diagnosed testicular mixed germ cell tumor with initial presentation of cutaneous metastasis at scalp and upper abdomen. After radical orchiectomy and four courses of cisplatin-based chemotherapy the scalp and upper abdominal lesions regressed completely. The size of lung metastases remained unchanged. Conclusions For advanced stage testicular cancer cisplatin-based chemotherapy is still effective to achieve partial response. Background Cutaneous manifestation of an internal malignancy is rare with an incidence of 1 2 . The frequencies of skin metastases in females are 69 for breast cancer 9 for colon cancer and 5 for melanoma. In males the frequencies of cutaneous metastases are 24 for lung cancer 19 for colon cancer and 13 for melanoma 3 4 Cutaneous metastases of the genitourinary tract tumors have been associated with cancers of the prostate 5 bladder 6 and kidney 7 . This report describes a case of testicular germ cell tumor with skin metastases at the initial presentation. Case Presentation A 19-year-old male was in good health conditions before admission. He suffered progressively enlarging upper abdominal skin lesions and scalp nodules for 3 .