tailieunhanh - Báo cáo khoa học: "Expression of cell cycle proteins in male breast carcinoma"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Expression of cell cycle proteins in male breast carcinoma | Kanthan et al. World Journal of Surgical Oncology 2010 8 10 http content 8 1 10 WORLD JOURNAL OF SURGICAL ONCOLOGY RESEARCH Open Access Expression of cell cycle proteins in male breast carcinoma Rani Kanthan1 Isabella Fried2 Theresa Rueckl2 Jenna-Lynn Senger1 Selliah Chandra Kanthan3 Abstract Introduction Male breast cancer MBC is a rare yet potentially aggressive disease. Although literature regarding female breast cancer FBC is extensive little is known about the etiopathogenesis of male breast cancer. Studies from our laboratory show that MBCs have a distinct immunophenotypic profile suggesting that the etiopathogenesis of MBC is different from FBCs. The aim of this study was to evaluate and correlate the immunohistochemical expression of cell cycle proteins in male breast carcinoma to significant clinico-biological endpoints. Methods 75 cases of MBC were identified using the records of the Saskatchewan Cancer Agency over 26 years 1970-1996 . Cases were reviewed and analyzed for the immunohistochemical expression of PCNA Ki67 p27 p16 p57 p21 cyclin-D1 and c-myc and correlated to clinico-biological endpoints of tumor size node status stage of the disease and disease free survival DFS . Results Decreased DFS was observed in the majority of tumors that overexpressed PCNA 98 p . The overexpression of PCNA was inversely correlated to the expression of Ki67 which was predominantly negative . Cyclin D1 was overexpressed in of cases. Cyclin D1 positive tumors were smaller than 2 cm p had a low incidence of lymph node metastasis p and were associated with increased DFS of 150 months p . Overexpression of c-myc 90 was linked with a higher incidence of node negativity p and increased DFS p . p27 over expression was associated with decreased lymph node metastasis p . P21 and p57 positive tumors were related to decreased DFS p . Though p16 was overexpressed in this did not reach statistical