tailieunhanh - Báo cáo khoa học: "Gestational trophoblastic neoplasia with retroperitoneal metastases: A fatal complication"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Gestational trophoblastic neoplasia with retroperitoneal metastases: A fatal complication | Thomakos et al. World Journal of Surgical Oncology 2010 8 114 http content 8 1 114 5 t WORLD JOURNAL OF SURGICAL ONCOLOGY CASE REPORT Open Access Gestational trophoblastic neoplasia with retroperitoneal metastases A fatal complication Nikolaos Thomakos1 Alexandros Rodolakis1 Panayiotis Belitsos1 Flora Zagouri2 Ioannis Chatzinikolaou2 Athanassios-Meletios Dimopoulos2 Christos A Papadimitriou2 Aris Antsaklis1 Abstract Background Gestational Trophoblastic Neoplasia GTN is a pathologic entity that can affect any pregnancy and develop long after the termination of the pregnancy. Its course can be complicated by metastases to distant sites such as the lung brain liver kidney and vagina. The therapeutic approach of this condition includes both surgical intervention and chemotherapy. The prognosis depends on many prognostic factors that determine the stage of the disease. Case Report We present a woman with GTN and retroperitoneal metastatic disease who came to our department and was diagnosed as having high risk metastatic GTN. Accordingly she received chemotherapy as primary treatment but unfortunately developed massive bleeding after the first course of chemotherapy was operated in an attempt to control bleeding but finally succumbed. Conclusion This case demonstrates that GTN while usually curable can be a deadly disease requiring improved diagnostic treatment modalities and chemotherapeutic agents. The gynaecologist should be aware of all possible metastatic sites of GTN and the patient immediately referred to a specialist center for further assessment and treatment. Introduction Gestational Trophoblastic Neoplasia GTN refers to a pathologic condition that is characterized by aggressive invasion of the endometrium and myometrium by trophoblastic cells and is divided to four different pathologic entities invasive mole gestational choriocarcinoma placental site trophoblastic tumour and epithelioid trophoblastic tumour 1 . GTN typically develops with or .