tailieunhanh - Báo cáo khoa học: "Ductal carcinoma in situ and sentinel lymph node metastasis in breast cancer"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Ductal carcinoma in situ and sentinel lymph node metastasis in breast cancer | Tada et al. World Journal of Surgical Oncology 2010 8 6 http content 8 1 6 WORLD JOURNAL OF SURGICAL ONCOLOGY RESEARCH Open Access Ductal carcinoma in situ and sentinel lymph node metastasis in breast cancer Keiichiro Tada1 Akiko Ogiya2 Kiyomi Kimura1 Hidetomo Morizono1 Kotaro Iijima1 Yumi Miyagi1 Seiichiro Nishimura1 Masujiro Makita1 Rie Horii2 Futoshi Akiyama2 Takuji Iwase1 Abstract Background The impact of sentinel lymph node biopsy on breast cancer mimicking ductal carcinoma in situ DCIS is a matter of debate. Methods We studied the rate of occurrence of sentinel lymph node metastasis in 255 breast cancer patients with pure DCIS showing no invasive components on routine pathological examination. We compared this to the rate of occurrence in 177 patients with predominant intraductal-component IDC breast cancers containing invasive foci equal to or less than cm in size. Results Most of the clinical and pathological baseline characteristics were the same between the two groups. However peritumoral lymphatic permeation occurred less often in the pure DCIS group than in the IDC-predominant invasive-lesion group vs. p . One patient with pure DCIS had two sentinel lymph nodes positive for metastasis. This rate was significantly lower than that in patients with IDC-predominant invasive lesions p . Conclusions Because the rate of sentinel lymph node metastasis in pure DCIS is very low sentinel lymph node biopsy can safely be omitted. Introduction The technique of sentinel lymph node biopsy is used worldwide as a surgical treatment for breast cancer 1 2 . This procedure can accurately determine lymph node metastasis 3 4 . Therefore morbid axillary dissection can be safely avoided when sentinel lymph nodes are free from cancer 5 6 . The primary indication for sentinel lymph node biopsy is invasive breast cancer which has the potential of metastasizing to the regional lymph nodes. On the other hand ductal carcinoma in situ DCIS