tailieunhanh - Báo cáo khoa học: "A pre-operative elevated neutrophil: lymphocyte ratio does not predict survival from oesophageal cancer resection"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: A pre-operative elevated neutrophil: lymphocyte ratio does not predict survival from oesophageal cancer resection | Rashid et al. World Journal of Surgical Oncology 2010 8 1 http content 8 1 1 WORLD JOURNAL OF SURGICAL ONCOLOGY RESEARCH Open Access A pre-operative elevated neutrophil lymphocyte ratio does not predict survival from oesophageal cancer resection Farhan Rashid1 3 Naseem Waraich 1 Imran Bhatti1 3 Shopan Saha1 Raheela N Khan1 2 Javed Ahmed1 Paul C Leeder1 Mike Larvin1 3 Syed Y Iftikhar1 3 Abstract Background Elevated pre-operative neutrophil lymphocyte ratio NLR has been identified as a predictor of survival in patients with hepatocellular and colorectal cancer. The aim of this study was to examine the prognostic value of an elevated preoperative NLR following resection for oesophageal cancer. Methods Patients who underwent resection for oesophageal carcinoma from June 1997 to September 2007 were identified from a local cancer database. Data on demographics conventional prognostic markers laboratory analyses including blood count results and histopathology were collected and analysed. Results A total of 294 patients were identified with a median age at diagnosis of IQR 59-72 years. The median pre-operative time of blood sample collection was three days IQR 1-8 . The median neutrophil count was X 10-9 litre median lymphocyte count X 10-9 litre whilst the NLR was IQR . NLR did not prove to be a significant predictor of number of involved lymph nodes Cox regression p disease recurrence p or death Cox regression p . Furthermore survival time was not significantly different between patients with high or low NLR p . Conclusion Preoperative NLR does not appear to offer useful predictive ability for outcome disease-free and overall survival following oesophageal cancer resection. Introduction Human oesophageal carcinoma is considered one of the most aggressive malignancies and is associated with a poor prognosis 1 . Despite recent advancement in surgical and oncological treatment the five year survival